Human Herpes Virus 4 (HHV-4)(intracellular)
Direct contact with saliva: “Kissing disease”, saliva, drinking from the same glass, toothbrush, blood, sex, blood-transfusion, organ transplantation.
50 % of all five-year-old children and 90-95 % of adults in USA are seropositive.
Infectious Mononucleosis (glandular fever), malaise, anorexia, chills, fever, cervical lymphadenopathy, pharyngitis, splenomegaly, hepatitis, peripheral atypical lymphocytosis
Chronic Fatique Sydrome (CFS), autoimmune diseases (dermatomyositis, systemic lupus erythoematosus, rheumatoid arthritis, Sjögren´s syndrome), Multiple Scleroris, cancer (Hodgkin´s lymphoma, Burkitt´s lymphoma, nasopharyngeal carcinoma), conditions associated with HIV (hairy leukoplakia, central nervous system lyhmphomas)
immune suppression (children, elder people), young adults