Diseases
Zonulin
Zonulin is a human protein that binds to a specific receptor on the surface of epithelial cells of the intestinal barrier.
Understanding the Role of Zonulin in Gut Health and Autoimmune Disorders
Zonulin activates a cascade of biochemical events that induce the opening of tight junctions, thereby increasing the permeability of intestinal epithelial cells, allowing various substances to pass through the intestinal barrier and trigger autoimmune reactions.
It has been found that in patients with celiac disease and type 1 diabetes mellitus, the zonulin-zonulin receptor system is more strongly activated, resulting in an increased concentration of zonulin.
Zonulin is a protein that regulates the permeability of the intestinal barrier. An increase in zonulin can lead to increased permeability of the intestinal barrier, which is associated with various diseases, including inflammatory bowel diseases, celiac disease, autoimmune diseases, and other gastrointestinal and immune system disorders. Therefore, measuring zonulin in the blood can be helpful in assessing gut health.
Further informations
Zonulin
Regulatory Protein
Regulation of Intestinal Permeability:
- Zonulin regulates the permeability of the intercellular tight junctions of the intestinal epithelial cells.
- Under normal conditions, zonulin regulates the permeability of the intestinal barrier to allow the passage of nutrients.
- Disrupted Intestinal Barrier - 'Leaky Gut Syndrome'
- Imbalances in Zonulin regulation have been associated with various conditions, including inflammatory bowel diseases (IBD), celiac disease, and autoimmune disorders.
Impact on Health:
- Normal regulation of Zonulin is crucial for gut and overall health.
- An increase in Zonulin levels can be associated with various diseases related to disrupted intestinal permeability.
