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Zonulin

Zonulin is a human protein that binds to a specific receptor on the surface of epithelial cells of the intestinal barrier.

Understanding the Role of Zonulin in Gut Health and Autoimmune Disorders

Zonulin activates a cascade of biochemical events that induce the opening of tight junctions, thereby increasing the permeability of intestinal epithelial cells, allowing various substances to pass through the intestinal barrier and trigger autoimmune reactions.

It has been found that in patients with celiac disease and type 1 diabetes mellitus, the zonulin-zonulin receptor system is more strongly activated, resulting in an increased concentration of zonulin.

Zonulin is a protein that regulates the permeability of the intestinal barrier. An increase in zonulin can lead to increased permeability of the intestinal barrier, which is associated with various diseases, including inflammatory bowel diseases, celiac disease, autoimmune diseases, and other gastrointestinal and immune system disorders. Therefore, measuring zonulin in the blood can be helpful in assessing gut health.

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Zonulin

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Zonulin

Regulatorisches Protein

Regulation der Darmpermeabilität:

Zonulin reguliert die Permeabilität der interzellulären Tight Junctions (Verschlussverbindungen) der Darmepithelzellen.

Unter normalen Bedingungen reguliert Zonulin die Durchlässigkeit der Darmwand, um das Eindringen von Nährstoffen zu ermöglichen.

Gestörten Darmbarriere – "Leaky-Gut-Syndrom"

Gestörtes Gleichgewicht in der Zonulinregulation wird mit verschiedenen Erkrankungen in Verbindung gebracht, darunter entzündliche Darmerkrankungen (IBD), Zöliakie und Autoimmunerkrankungen.

Einfluss auf die Gesundheit:

Eine normale Zonulinregulation ist wichtig für die Gesundheit des Darms und des gesamten Körpers.

Ein Anstieg von Zonulin kann mit verschiedenen Krankheiten in Verbindung gebracht werden, die mit einer gestörten Darmpermeabilität verbunden sind.